Ruyue Xin

Master's degree, Research Assistant, Laboratory Manager

Email: xinruyue@@gdiist.cn

Personal Profile：

Graduated with a Bachelor's degree in Bioscience (Base Class) from Shaanxi Normal University in 2020, and obtained a Master's degree in Genetics from the Model Animal Research Center of Nanjing University Medical School in 2023.

During the master's program, the research focus was on the immune regulation of physiological homeostasis and the complex diseases arising from its dysregulation. The primary work involved studying the physiological function of GSDMB in inflammatory bowel disease (IBD).

Awards and honors include Outstanding Graduate Student, Outstanding Graduate Student Cadre, and First-Class Academic Scholarship from Nanjing University.

Research Directions：

Brain cognition and myelin development

Works：

1. Li, X., Zhang, T., Kang, L., Xin, R., Sun, M., Chen, Q., Pei, J., Chen, Q., Gao, X., & Lin, Z. (2023). Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage. Cell death and differentiation.

2. Liu, Q., Li, M., Sun, M., Xin, R., Wang, Y., Chen, Q., Gao, X., & Lin, Z. (2024). Depletion of Gsdma1/2/3 alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR-Stat3/Akt pathway. Journal of molecular cell biology.

3. Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Immunity.